short answer.
yes, you can.
I have done it....but not often.
it depends on how far off the side you want to run your inline boards, or how far you want to run your lines to the side on a mast system.
you will have a "dip" in your line due to the weight of the leadcore going to the board.
Now, as long as that "dip" stays above the water line, your ok...
but if you run your boards too far to the side, and that dip starts to touch the surface of the water, that's when "I" feel you start to be at a disadvantage.
Hope this helps.
Cheers,
Steve